Half Life Pharmacology at Life

Half Life Pharmacology. In pharmacology, when we talk about the half life of a drug we usually mean the time it takes a drug's concentration in the blood plasma to reduce by half. (t 1/2), the time required to decrease the amount of drug in body by 1/2 during elimination (or during a constant infusion).

It can vary from a few hours to a few days, or sometimes weeks. Most of the drugs have alpha half life and remain in the plasma. It has high oral bioavailability (60.

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That is, the higher the clearance, the less time the drug spends in the systemic circulation and the faster the decline in the plasma drug concentration. Therefore, in such situations, the body exposure. Half life of a drug is directly proportional to the volume of the distribution and inversely proportional to the clearance. Alpha half life = plasma / distribution half life.